Yes it is safe only for itemstats mod.. the best is 10x itemstats mod.. trust me..
How I know is I tested all the mods in 11 different accounts over 1 and a half year.. The one that is the safest is itemstats mod .. all was banned expect itemstats mod..
According to my experience in the game...
Yeah... When using hacks.. just rmb not to use it in guild raid, world boss and hell story if your team is not fully T2 with good equips.. ToC, ToO, ancient vault and hell stock is safe.. as for pvp and dragon raids, the hacks wont work..